Senior Genomics Scientist, Verge Genomics (since April 2016)
I'm a scientist in the biotech industry who uses genomics to accelerate drug discovery. My expertise is in the spatiotemporal functional patterning and evolution of brain gene expression, how and why this is disrupted in neurological disorders and neurodegenerative diseases, and how multilevel integration of a wide variety of datasets can drive more effective target identification and lead generation. I'm also interested in the business of biotech. A computational biologist, I've worked remotely most of my career. Outside of work I volunteer for several science and education causes and serve on the board of the Mid-Bay Bridge Rotary Club of Niceville, Florida.
"Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons” Yingxiao Shi, Shaoyu Lin, Kim A Staats, Yichen Li, Wen-Hsuan Chang, Shu-Ting Hung, Eric Hendricks, Gabriel R Linares, Yaoming Wang, Esther Y Son, Xinmei Wen, Kassandra Kisler, Brent Wilkinson, Louise Menendez, Tohru Sugawara, Phillip Woolwine, Mickey Huang, Michael J Cowan, Brandon Ge, Nicole Koutsodendris, Kaitlin P Sandor, Jacob Komberg, Vamshidhar R Vangoor, Ketharini Senthilkumar, Valerie Hennes, Carina Seah, Amy R Nelson, Tze-Yuan Cheng, Shih-Jong J Lee, Paul R August, Jason A Chen, Nicholas Wisniewski, Victor Hanson-Smith, T Grant Belgard, Alice Zhang, Marcelo Coba, Chris Grunseich, Michael E Ward, Leonard H van den Berg, R Jeroen Pasterkamp, Davide Trotti, Berislav V Zlokovic, Justin K Ichida. Nature Medicine (2018).
"Significant transcriptional changes in 15q duplication but not Angelman syndrome deletion stem cell-derived neurons" Nora Urraca, Kevin Hope, A Kaitlyn Victor, T Grant Belgard, Rawaha Memon, Sarita Goorha, Colleen Valdez, Quynh T Tran, Silvia Sanchez, Juanma Ramirez, Martin Donaldson, Dave Bridges, Lawrence T Reiter. Molecular Autism (2018).
"Endothelium-derived extracellular vesicles promote splenic monocyte mobilisation in myocardial infarction" Naveed Akbar, Janet Digby, Thomas J Cahill, Abhijeet N Tavare, Alastair L Corbin, Sushant Saluja, Sam Dawkins, Laurienne Edgar, Nadiia Rawlings, Klemen Ziberna, Eileen McNeill, Oxford Acute Myocardial Infarction (OxAMI) Study, Errin Johnson, Alaa A Aljabali, Rebecca A Dragovic, Mala Rohling, T Grant Belgard, Irina A Udalova, David R Greaves, Keith M Channon, Paul R Riley, Daniel C Anthony, Robin P Choudhury. JCI Insight (2017).
"An Immunoaffinity-Based Method for Isolating Ultrapure Adult Astrocytes Based on ATP1B2 Targetting by the ACSA-2 Antibody" Mykhailo Y. Batiuk, Filip de Vin, Sandra I. Duqué, Chen Li, Takashi Saito, Takaomi Saido, Mark Fiers, T. Grant Belgard, Matthew G. Holt. The Journal of Biological Chemistry (2017).
"Genome-wide changes in lncRNA, alternative splicing, and regional gene expression patterns in autism" Neelroop N Parikshak*, Vivek Swarup*, T Grant Belgard*, Manuel Irimia, Gokul Ramaswami, Michael J Gandal, Christopher Hartl, Virpi Leppa, Luis de la Torre Ubieta, Jerry Huang, Jennifer K Lowe, Benjamin J Blencowe, Steve Horvath, Daniel H Geschwind. Nature (2016).
"Histone Acetylome-wide Association Study of Autism Spectrum Disorder" Wenjie Sun, Jeremie Poschmann, Ricardo Cruz-Herrera del Rosario, Neelroop N Parikshak, Hajira Shreen Hajan, Vibhor Kumar, Ramalakshmi Ramaswamy, T Grant Belgard, Bavani Elanggovan, Chloe Chung Yi Wong, Jonathan Mill, Daniel H Geschwind, Shyam Prabhakar. Cell (2016).
"Elevated gene expression of most microglial markers, and reduced expression of most pyramidal neuron and interneuron markers, in postmortem autism cortex" Rebeca Borges-Monroy, Chris Ponting*, T Grant Belgard*. bioRxiv preprint (2015).
"Correspondence between resting state activity and brain gene expression" Guang-Zhong Wang*, T Grant Belgard*, Deng Mao, Leslie Chen, Stefano Berto, Todd M Preuss, Hanzhang Lu, Daniel H Geschwind, Genevieve Konopka. Neuron (2015). (PDF)
"Adult pallium transcriptomes surprise in not reflecting predicted homologies across diverse chicken and mouse pallial sectors" T Grant Belgard*, Juan F Montiel, Wei Zhi Wang, Fernando Garcia-Moreno, Elliott H Margulies, Chris P Ponting*, Zoltán Molnár*. Proceedings of the National Academy of Sciences of the United States of America (2013). (free PDF)
"Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia" Anna Hoerder-Suabedissen, Franziska M Oeschger, Michelle L Krishnan, T Grant Belgard, Wei Zhi Wang, Sheena Lee, Caleb Webber, Enrico Petretto, A David Edwards, Zoltán Molnár. Proceedings of the National Academy of Sciences of the United States of America (2013). (free PDF)
"The genomic landscape shaped by selection on transposable elements across 18 mouse strains" Christoffer Nellaker, Thomas M Keane, Binnaz Yalcin, Kim Wong, Avigail Agam, T Grant Belgard, Jonathan Flint, David J Adams, Wayne N Frankel, Chris P Ponting. Genome Biology (2012). (free PDF)
"Mouse genomic variation and its effect on phenotypes and gene regulation" Thomas M Keane, Leo Goodstadt, Petr Danecek, Michael A White, Kim Wong, Binnaz Yalcin, Andreas Heger, Avigail Agam, Guy Slater, Martin Goodson, Nicholas A Furlotte, Eleazar Eskin, Christoffer Nellåker, Helen Whitley, James Cleak, Deborah Janowitz, Polinka Hernandez-Pliego, Andrew Edwards, T Grant Belgard, Peter L Oliver, Rebecca E McIntyre, Amarjit Bhomra, Jérôme Nicod, Xiangchao Gan, Wei Yuan, Louise van der Weyden, Charles A Steward, Sendu Bala, Jim Stalker, Richard Mott, Richard Durbin, Ian J Jackson, Anne Czechanski, José Afonso Guerra-Assunção, Leah Rae Donahue, Laura G Reinholdt, Bret A Payseur, Chris P Ponting, Ewan Birney, David J Adams. Nature (2011). (free PDF; cited by)
In the news: TheScientist
"A Transcriptomic Atlas of Mouse Neocortical Layers" T Grant Belgard, Ana C Marques, Peter L Oliver, Hatice Ozel Abaan, Tamara M Sirey, Anna Hoerder-Suabedissen, Fernando Garcia-Moreno, Zoltán Molnár, Elliott H Margulies, Chris P Ponting. Neuron (2011). (free PDF; cited by)
On the cover:
Editorial: What's in a Name?
#1 most downloaded article in Neuron (Aug 30 - Sept 23, 2011)
"NSF Workshop Report: Discovering General Principles of Nervous System Organization by Comparing Brain Maps Across Species" Georg F Striedter, T Grant Belgard, Chun-Chun Chen, Fred P Davis, Barbara L Finlay, Onur Güntürkün, Melina E Hale, Julie A Harris, Erin E Hecht, Patrick R Hof, Hans A Hofmann, Linda Z Holland, Andrew N Iwaniuk, Erich D Jarvis, Harvey J. Karten, Paul S Katz, William B Kristan, Eduardo R Macagno, Partha P Mitra, Leonid L Moroz, Todd M Preuss, Clifton W Ragsdale, Chet C Sherwood, Charles F Stevens, Maik C Stüttgen, Tadaharu Tsumoto, Walter Wilczynski. Brain, Behavior and Evolution and Journal of Comparative Neurology (2014). (free PDF)
"Things Change: How Comparative Transcriptomics Suggest the Pallium Has Evolved at Multiple Levels of Organization" T Grant Belgard* and Juan F Montiel. Brain, Behavior and Evolution (2013). (free PDF)
Invited speaker. The Brain Mosaic: Cellular Heterogeneity in the CNS. Leuven, Belgium, 2016.
Invited speaker. Single Cell Analysis. Leuven, Belgium, 2016.
Speaker. Human Brain Project Summit, Madrid, Spain, 2015.
Invited speaker. VIB Center for the Biology of Disease, Leuven, Belgium, 2015.
Invited speaker. Department of Genetics, Genomics and Informatics, UTHSC, Memphis, TN, 2014.
Invited speaker. Dup15q Alliance - Angelman Syndrome Foundation Joint Scientific Meeting, Boston, MA, 2014.
Invited speaker. Dup15q Alliance Scientific Meeting, Davis, CA, 2013.
Speaker. American College of Neuropsychopharmacology, Hollywood, FL, 2012.
Invited speaker. Section on Neuroendocrinology, National Institute of Child Health and Human Development, Bethesda, MD, 2011.
Speaker. NIH Solexa (Illumina) User Group, Bethesda, MD, 2011.
Invited speaker. MRC Functional Genomics Unit Retreat, Steventon, UK, 2011.
Invited speaker. Oxford University Cortex Club, Oxford, UK, 2011.
Speaker. NIH-Oxford-Cambridge Colloquium, Cambridge, UK, 2010.
Substitute speaker. Annual Oxford Developmental Biology Symposium, Oxford, UK, 2009.
Speaker. Functional Genomics and Systems Biology Workshop, Wellcome Trust Conference Centre, Hinxton, UK, 2009.
Speaker. Genome Informatics, Cold Spring Harbor Laboratory, Long Island, NY, 2009.
Science, Nature Neuroscience, Nature Genetics, Neuron, Molecular Psychiatry, Nature Communications, European Journal of Neuroscience, PLOS Genetics, PLOS Biology, Journal of Comparative Neurology, BMC Biology, BMC Genomics, PLOS ONE, Tumor Biology, Cerebral Cortex, Molecular Brain, Genome Medicine, Computers in Biology and Medicine, Rubriq (platform for portable peer review)
Rice University Outstanding Senior Award
Louisiana School for Math, Science and the Arts Hall of Fame