Senior Genomics Scientist, Verge Genomics (San Francisco, CA)

I study the spatiotemporal functional patterning and evolution of brain gene expression, how and why this is disrupted in neurological disorders and neurodegenerative diseases, and how multilevel integration of a wide variety of datasets can drive more effective drug discovery. Previously a research scientist at Oxford University, I did a postdoctoral fellowship at UCLA, a DPhil in Physiology, Anatomy and Genetics at Oxford University and the National Institutes of Health, and graduated from Rice University with a BA in Biochemistry and Cell Biology and a BS in Physics, Chemistry and Chemical Physics. Besides science, I've interests in sailing, education, music and biotech consultancy. I am a member of the Mid-Bay Bridge Rotary Club of Niceville, FL, and a former (board) member of the Rotary Club of Beavercreek, OH.

Research Articles

"Genome-wide changes in lncRNA, alternative splicing, and cortical patterning in autism" Neelroop N Parikshak*, Vivek Swarup*, T Grant Belgard*, Manuel Irimia, Gokul Ramaswami, Michael J Gandal, Christopher Hartl, Virpi Leppa, Luis de la Torre Ubieta, Jerry Huang, Jennifer K Lowe, Benjamin J Blencowe, Steve Horvath, Daniel H Geschwind. Nature (in press, preprint linked).

*co-first authors

"Histone Acetylome-wide Association Study of Autism Spectrum Disorder" Wenjie Sun, Jeremie Poschmann, Ricardo Cruz-Herrera del Rosario, Neelroop N Parikshak, Hajira Shreen Hajan, Vibhor Kumar, Ramalakshmi Ramaswamy, T Grant Belgard, Bavani Elanggovan, Chloe Chung Yi Wong, Jonathan Mill, Daniel H Geschwind, Shyam Prabhakar. Cell (in press).

"Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder" Ye E Wu, Neelroop N Parikshak, T Grant Belgard, Daniel H Geschwind. Nature Neuroscience (2016).

"Elevated gene expression of most microglial markers, and reduced expression of most pyramidal neuron and interneuron markers, in postmortem autism cortex" Rebeca Borges-Monroy, Chris Ponting*, T Grant Belgard*. bioRxiv preprint (2015).

*co-corresponding authors

"Correspondence between resting state activity and brain gene expression" Guang-Zhong Wang*, T Grant Belgard*, Deng Mao, Leslie Chen, Stefano Berto, Todd M Preuss, Hanzhang Lu, Daniel H Geschwind, Genevieve Konopka. Neuron (2015). (PDF)

*co-first authors

"Adult pallium transcriptomes surprise in not reflecting predicted homologies across diverse chicken and mouse pallial sectors" T Grant Belgard*, Juan F Montiel, Wei Zhi Wang, Fernando Garcia-Moreno, Elliott H Margulies, Chris P Ponting*, Zoltán Molnár*. Proceedings of the National Academy of Sciences of the United States of America (2013). (free PDF)

*co-corresponding authors

"Population structure confounds autism genetic classifier" T Grant Belgard, Ivana Jankovic, Jennifer K Lowe, Daniel H Geschwind. Molecular Psychiatry (2013).

"Expression profiling of mouse subplate reveals a dynamic gene network and disease association with autism and schizophrenia" Anna Hoerder-Suabedissen, Franziska M Oeschger, Michelle L Krishnan, T Grant Belgard, Wei Zhi Wang, Sheena Lee, Caleb Webber, Enrico Petretto, A David Edwards, Zoltán Molnár. Proceedings of the National Academy of Sciences of the United States of America (2013). (free PDF)

"The genomic landscape shaped by selection on transposable elements across 18 mouse strains" Christoffer Nellaker, Thomas M Keane, Binnaz Yalcin, Kim Wong, Avigail Agam, T Grant Belgard, Jonathan Flint, David J Adams, Wayne N Frankel, Chris P Ponting. Genome Biology (2012). (free PDF)

"Water-Phase Synthesis of Cationic Silica/Polyamine Nanoparticles" Quang X Nguyen, T Grant Belgard, John J Taylor, Vinit S Murthy, Naomi J Halas, Michael S Wong. Chemistry of Materials (2012).

"Mouse genomic variation and its effect on phenotypes and gene regulation" Thomas M Keane, Leo Goodstadt, Petr Danecek, Michael A White, Kim Wong, Binnaz Yalcin, Andreas Heger, Avigail Agam, Guy Slater, Martin Goodson, Nicholas A Furlotte, Eleazar Eskin, Christoffer Nellåker, Helen Whitley, James Cleak, Deborah Janowitz, Polinka Hernandez-Pliego, Andrew Edwards, T Grant Belgard, Peter L Oliver, Rebecca E McIntyre, Amarjit Bhomra, Jérôme Nicod, Xiangchao Gan, Wei Yuan, Louise van der Weyden, Charles A Steward, Sendu Bala, Jim Stalker, Richard Mott, Richard Durbin, Ian J Jackson, Anne Czechanski, José Afonso Guerra-Assunção, Leah Rae Donahue, Laura G Reinholdt, Bret A Payseur, Chris P Ponting, Ewan Birney, David J Adams. Nature (2011). (free PDFcited by)

In the news: TheScientist

"A Transcriptomic Atlas of Mouse Neocortical Layers" T Grant Belgard, Ana C Marques, Peter L Oliver, Hatice Ozel Abaan, Tamara M Sirey, Anna Hoerder-Suabedissen, Fernando Garcia-Moreno, Zoltán Molnár, Elliott H Margulies, Chris P Ponting. Neuron (2011). (free PDFcited by)

On the cover:


Editorial: What's in a Name?

In the news: MedscapeSFARIGenomeWebNIHUniversity of OxfordWellcome Trust

#1 most downloaded article in Neuron (Aug 30 - Sept 23, 2011)

Reviews, Commentaries, Workshop Reports

"The Emerging Picture of Autism Spectrum Disorders: Genetics and Pathology" Jason A Chen, Olga Peñagarikano, T Grant Belgard, Vivek Swarup, Daniel H Geschwind. Annual Review of Pathology (2015).

"NSF Workshop Report: Discovering General Principles of Nervous System Organization by Comparing Brain Maps Across Species" Georg F Striedter, T Grant Belgard, Chun-Chun Chen, Fred P Davis, Barbara L Finlay, Onur Güntürkün, Melina E Hale, Julie A Harris, Erin E Hecht, Patrick R Hof, Hans A Hofmann, Linda Z Holland, Andrew N Iwaniuk, Erich D Jarvis, Harvey J. Karten, Paul S Katz, William B Kristan, Eduardo R Macagno, Partha P Mitra, Leonid L Moroz, Todd M Preuss, Clifton W Ragsdale, Chet C Sherwood, Charles F Stevens, Maik C Stüttgen, Tadaharu Tsumoto, Walter Wilczynski. Brain, Behavior and Evolution and Journal of Comparative Neurology (2014). (free PDF)

"Things Change: How Comparative Transcriptomics Suggest the Pallium Has Evolved at Multiple Levels of Organization" T Grant Belgard* and Juan F Montiel. Brain, Behavior and Evolution (2013). (free PDF)

*corresponding author

"Retooling spare parts: gene duplication and cognition" T Grant Belgard and Daniel H Geschwind. Nature Neuroscience (2012).

"Transcriptional Profiling of Layers of the Primate Cerebral Cortex" Zoltán Molnár* and T Grant Belgard*. Neuron (2012).

*co-corresponding authors

"Transcribed dark matter: meaning or myth?" Chris P Ponting and T Grant BelgardHuman Molecular Genetics (2010). (free PDFcited by)

Book Chapters

"Chapter 4: Transcriptomics" T Grant Belgard and Daniel H Geschwind, The OMICs: Applications in Neuroscience, Oxford University Press (2014).


"SCALABLE PROCESS FOR SYNTHESIZING UNIFORMLY-SIZED COMPOSITE NANOPARTICLES". Vinit S Murthy, Tildon G Belgard, and Michael S Wong. United States Patent Application 20100222501 (2006).



Web Interfaces

A Transcriptomic Atlas of Mouse Neocortical Layers

CORTx: A Functional Browser for the Transcriptomes of Neocortical Layers

Platform Talks

Invited speaker. The Brain Mosaic: Cellular Heterogeneity in the CNS. Leuven, Belgium, 2016.

Invited speaker. Single Cell Analysis. Leuven, Belgium, 2016.

Speaker. Human Brain Project Summit, Madrid, Spain, 2015.

Invited speaker. VIB Center for the Biology of Disease, Leuven, Belgium, 2015.

Invited speaker. Department of Genetics, Genomics and Informatics, UTHSC, Memphis, TN, 2014.

Invited speaker. Dup15q Alliance - Angelman Syndrome Foundation Joint Scientific Meeting, Boston, MA, 2014.

Invited speaker. Dup15q Alliance Scientific Meeting, Davis, CA, 2013.

Speaker. American College of Neuropsychopharmacology, Hollywood, FL, 2012.

Invited speaker. Section on Neuroendocrinology, National Institute of Child Health and Human Development, Bethesda, MD, 2011.

Speaker. NIH Solexa (Illumina) User Group, Bethesda, MD, 2011.

Invited speaker. MRC Functional Genomics Unit Retreat, Steventon, UK, 2011.

Invited speaker. Oxford University Cortex Club, Oxford, UK, 2011.

Speaker. NIH-Oxford-Cambridge Colloquium, Cambridge, UK, 2010.

Substitute speaker. Annual Oxford Developmental Biology Symposium, Oxford, UK, 2009.

Speaker. Functional Genomics and Systems Biology Workshop, Wellcome Trust Conference Centre, Hinxton, UK, 2009.

Speaker. Genome Informatics, Cold Spring Harbor Laboratory, Long Island, NY, 2009.

Invited Reviewer

Nature Neuroscience, Nature Genetics, Neuron, Molecular Psychiatry, Nature Communications, European Journal of Neuroscience, PLOS Genetics, PLOS Biology, Journal of Comparative Neurology, BMC Biology, BMC Genomics, PLOS ONE, Tumor Biology, Cerebral Cortex, Molecular Brain, Genome Medicine, Rubriq (platform for portable peer review)

Selected Awards

Marshall Scholar (SallyportRice News)

NIH-Oxford Scholar (Rice News)

Rice University Outstanding Senior Award

Louisiana School for Math, Science and the Arts Hall of Fame